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  1. Due to wide dissemination at presentation in most patients, the disease prognosis is often poor, with 5 year survival as low as 58 priligy and cialis together Similarly, an elegant series of studies has highlighted the importance of 11beta HSD for immune regulation by glucocorticoids Hennebold Daynes, 1998 and shown that increased activity of the enzyme that results in lower glucocorticoid concentrations results in Th1 type immune responses, whereas decreased activity promotes Th2 type responses Hennebold, Ryu, Mu, Galbraith Daynes, 1996

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